姚露露
姚露露 研究生导师
职位:副研究员 学位: 博士
学院: 针灸康复临床医学院(华南针灸研究中心)
Email: yaolulu@gzucm.edu.cn
办公电话: 39354101
办公室: 广州大学城广州中医药大学针灸楼506
教育、工作经历:
2010-2014: 四川大学
2014-2019: 北京大学
2019-2021: 广州中医药大学博士后
2021-至今: 广州中医药大学 华南针灸研究中心
研究方向:
应用神经生物学前沿技术包括化学遗传、光遗传、在体以及离体电生理技术研究针灸治疗脑病包括中风、情志疾病等的作用机理,夯实中医针灸治疗方法的理论,为中医药的国际化提供证据。
课题:
1. 广州市基础与应用基础研究项目—一般项目(博士青年科技人员类),基于LHbPV-VTA环路研究针刺对早期压力应激诱导抑郁的作用机制,2023-01-01至2025-12-31,5万元,主持,在研
2. 广东省自然科学基金面上项目,2024A1515012282,基于5-HT和钾离子通道相互调控研究电针治疗中风后抑郁的作用机制,2024-01-01至2026-12-31,15万元,主持,在研
3. 博士后面上基金, 2020M672601,基于神经周围基质研究电针廉泉穴治疗中风后吞咽障碍对兴奋性/抑制性平衡的调控作用, 8万元,主持,结题
4. 国家青年科学基金项目,82004469,电针百会、大椎调控缺血性中风患侧不同类型神经元及其NMDARs的机制研究,24万元,主持,结题
代表性论文:
1. Lulu Yao(第一作者), Qiuping Ye, Yun Liu, Shuqi Yao, Si Yuan, Qin Xu, Bing Deng, Xiaorong Tang, Jiahui Shi, Jianyu Luo, Junshang Wu, Zhennan Wu, Jianhua Liu, Chunzhi Tang, Lin Wang* & Nenggui Xu*;Electroacupuncture improves swallowing function in a post-stroke dysphagia mouse model by activating the motor cortex inputs to the nucleus tractus solitarii through the parabrachial nuclei, Nature Communications, 2023, Feb 13;14(1):810. doi: 10.1038/s41467-023-36448-6. (IF=17.6)
2. Lulu Yao(第一作者), Yi Rong, Xiaoyan Ma, Haifu Li, Di Deng, Yongjun Chen, Sungchil Yang, Tao Peng, Tao Ye, Feixue Liang, Nenggui Xu, Qiang Zhou*. Extrasynaptic NMDA Receptors Bidirectionally Modulate Intrinsic Excitability of Inhibitory Neurons. Journal of Neuroscience.2022;42(15):3066-3079. (IF=6.1)
3.Si Yuan#, Bing Deng#, Qiuping Ye, Zhennan Wu, Junshang Wu, Lin Wang, Qin Xu, Lulu Yao*(共同通讯作者), Nenggui Xu*. Excitatory neurons in paraventricular hypothalamus contributed to the mechanism underlying acupuncture regulating the swallowing function. Scientific Reports.2022,12(1):5797. (IF=4.4)
4. Yao L(第一作者), Yuan S, Wu ZN, Luo JY, Tang XR, Tang CZ, Cui S, Xu NG. Contralateral S1 function is involved in electroacupuncture treatment-mediated recovery after focal unilateral M1 infarction. Neural Regen Res. 2022 Jun;17(6):1310-1317. doi: 10.4103/1673-5374.327355. (IF=5.1)
5. Yao L(第一作者), Wang Z, Deng D, Yan R, Ju J, Zhou Q. The impact of D-cycloserine and sarcosine on in vivo frontal neural activity in a schizophrenia-like model. BMC Psychiatry. 2019 Oct 25;19(1):314. doi: 10.1186/s12888-019-2306-1. (IF=3.3)
6. Yao L(第一作者), Grand T, Hanson JE, Paoletti P, Zhou Q. Higher ambient synaptic glutamate at inhibitory versus excitatory neurons differentially impacts NMDA receptor activity. Nat Commun. 2018 Oct 1;9(1):4000. doi: 10.1038/s41467-018-06512-7. (IF=17.6)
7. Yao L(第一作者), Zhou Q. Enhancing NMDA Receptor Function: Recent Progress on Allosteric Modulators. Neural Plast. 2017:2017:2875904. doi: 10.1155/2017/2875904. (IF=3.6)
8.Si Yuan, Bo Qiu, Ying Liang, Bing Deng, Jing Xu, Xiaorong Tang, Junshang Wu, Sheng Zhou, Zeli Li, Hongzhu Li, Qiuping Ye, Lin Wang, Shuai Cui, Chunzhi Tang, Wei Yi, Lulu Yao(共同通讯作者), Nenggui Xu. Role of TRPV1 in electroacupuncture-mediated signal to the primary sensory cortex during regulation of the swallowing function. CNS Neurosci Ther. 2023 Sep 18. doi: 10.1111/cns.14457. (IF=7.0)
9. Si Yuan, Jiahui Shi, Xiaorong Tang, Bing Deng, Zhennan Wu, Bo Qiu, Shumin Lin, Chang Ji, Lin Wang, Shuai Cui, Nenggui Xu, Lulu Yao(通讯作者).The Role of Perineuronal Nets in the Contralateral Hemisphere in the Electroacupuncture-Mediated Rehabilitation of Poststroke Dysphagia Mice. eNeuro. 2023 Dec 5;10(12):ENEURO.0234-23.2023. doi: 10.1523/ENEURO.0234-23.2023. (IF=3.4)
10. Junshang Wu, Libo Hua, Wenhao Liu, Xiaoyun Yang, Xiaorong Tang, Si Yuan, Sheng Zhou, Qiuping Ye, Shuai Cui, Zhennan Wu, Lanfeng Lai, Chunzhi Tang, Lin Wang, Wei Yi, Lulu Yao(共同通讯作者), Nenggui Xu. Electroacupuncture Exerts Analgesic effects by Restoring Hyperactivity via Cannabinoid Type 1 Receptors in the Anterior Cingulate Cortex in Chronic Infammatory Pain. Mol Neurobiol. 2023 Nov 13. doi: 10.1007/s12035-023-03760-7 (IF=5.5)
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